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| ZUGNO,ALEXANDRA I.; CANEVER,LARA; MASTELLA,GUSTAVO; HEYLMANN,ALEXANDRA S.; OLIVEIRA,MARIANA B.; STECKERT,AMANDA V.; CASTRO,ADALBERTO A.; PIZZOL,FELIPE DAL; QUEVEDO,JOÃO; GAMA,CLARISSA S.. |
| ABSTRACTNew studies suggest that polyunsaturated fatty acids, such as omega-3, may reduce the symptoms of schizophrenia. The present study evaluated the preventive effect of omega-3 on interleukines (IL) and neurotrophin brain-derived neurotrophic factor (BDNF) levels in the brains of young rats subjected to a model of schizophrenia. Treatment was performed over 21 days, starting on the 30th day of rat's life. After 14 days of treatment with omega-3 or vehicle, a concomitant treatment with saline or ketamine (25 mg/kg) was started and maintained until the last day of the experiment. BDNF levels in the rat's prefrontal cortex were decreased at 1 h and 24 h after the last administration of ketamine, whereas the group administered with ketamine and omega-3... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Omega-3; Ketamine; Schizophrenia; Neurotrophins; Interleukins. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301475 |
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